The use of loperamide for self-managing opioid addiction is becoming an increasingly prevalent public health concern
5) and the two main repolarizing cardiac K(+)
Loperamide’s cardiotoxicity comes from inhibiting sodium and potassium channels
QRS and QTc prolongation
Further, molecular investigations revealed increased expression of ion channels such as TRPA1, TRPM8; voltage-gated sodium channels (VGSCs) and
[4] The recommended daily maximum dose is 16 mg for the indication of